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Signalisation rédox, protéines FeS

Signalisation redox et fonction des protéines Fe-S



The research of our group is focused on the structure-function of iron-sulfur cluster (Fe-S) proteins and redox signaling.

We aim to understand how Fe-S clusters are assembled in mitochondria and exported to the cytosolic compartment, using mammalian cellular models. In addition, the cellular stress response remains at the core of our activity and directly linked to particular redox sensing Fe-S cluster proteins. Fe-S cluster proteins, present in different cell compartments, are involved in critical biological processes including respiration, DNA synthesis and repair, iron homeostasis and heme synthesis. While the list of newly identified Fe-S cluster proteins is growing every year, structure-function relationship of most of Fe-S proteins is still unknown.

Our research in the past few years has improved the understanding of the biological function of mammalian Fe-S proteins, especially those classified as redox sensor proteins.

Our group is affiliated to :
- the FrenchBIC, Groupe Français de Chimie Bio-Inorganique,
- the European COST Action CA15133 "The Biogenesis of Iron-Sulfur Proteins : from Cellular Biology to Molecular Aspects",
- the European COST Action BM1203 "Oxidative Stress and Redox Biology Research",
- the Société Française de Biologie Cellulaire,
- the Société Française de Biochimie et Biologie Moléculaire.